博士招生｜英国布里斯托大学、谢菲尔德大学博士招生项目推荐

　　

　　1

　　University of Bristol

　　布里斯托大学

　　布里斯托大学（University of Bristol），世界百强名校，始建于1876年，位于英格兰西南部城市布里斯托。同时属于红砖大学 、罗素大学集团、科英布拉集团、世界大学联盟、国际大学气候联盟、欧洲大学协会成员。

　　布里斯托大学综合排名强劲：2023QS世界大学排名第61名，2020软科世界大学学术排名第64名，2023泰晤士高等教育世界大学排名第76名，2021U.S. News世界大学排名第86名。

　　Machine Learning for

　　Long-Term Video?Understanding

　　1?? Dr D Aldamen

　　2?? Friday, February 10, 2023

　　3?? Competition Funded PhD Project

　　About the Project

　　Applications are invited for one fully funded PhD studentships in Computer?Vision and Machine Learning on the topic of Long-Term Video Understanding.

　　The successful applicant will work in a vibrant computer Machine Learning and Computer Vision lab, with more than 7 PhD students and 3 postdoctoral researchers working on closely related topics. For an insight into the supervisors’ current and previous works, refer to:

　　https://dimadamen.github.io/

　　Candidate Requirements

　　Applicants must hold/achieve a minimum of a Master’s degree (or international equivalent) in computer science, mathematics or other relevant discipline.?Applicants without a Master’s qualification may be considered on an exceptional basis, provided they hold a first-class undergraduate degree. Please note, acceptance will also depend on evidence of readiness to pursue a research degree.

　　Basic skills and knowledge required:

　　·Essential:

　　Solid mathematical ability and excellent programming skills.?A basic knowledge of Machine Learning and Computer Vision (very useful).?An Interest in research and loads of patience.

　　·Desirable (not necessary):

　　Prior research expertise in video, language, audio understanding or any combination of these modalities.

　　

　　2

　　The University of Sheffield

　　谢菲尔德大学

　　谢菲尔德大学（The University of Sheffield）英国研究型大学，位于英国英格兰南约克郡的谢菲尔德市，建校历史可追溯至1828年的谢菲尔德医学院。同属世界百强大学、英国红砖大学，世界大学联盟、罗素大学集团等成员。2012年管理学院获得AACSB、AMBA和EQUIS三大认证。

　　作为红砖大学之一，有6位诺贝尔奖获得者毕业于谢菲尔德大学或为该校长期工作的研究人员。他们为青霉素的开发、柠檬酸循环的发现、高速化学反应的研究、真核DNA中内含子的发现、富勒烯的发现以及分子机器的发展做出了贡献。

　　Synthetic Biology-Based Poly-merase and Promoter En-gineering for Production of Next-Generatiom?RNA Therapeutics

　　1?? Dr Adam Brown,?Prof Tuck Wong

　　2?? Monday, January 23, 2023

　　3??Competition Funded PhD Project

　　About the Project

　　A fully funded BBSRC-AZ CASE PhD studentship is available in the Department of Chemical and Biological Engineering at the University of Sheffield, starting in October 2023.

　　The therapeutic promise of mRNA-based biopharmaceuticals was realised when they formed the backbone of the world’s vaccination programme against Covid-19. Beyond vaccines, they also have application in gene therapy, offering potential to treat many currently incurable conditions including cancer, neurological disorders and cardiovascular diseases. However, much is still unknown regarding how the fundamental components of mRNA manufacturing systems (the RNA Polymerase and DNA template) mechanistically interact to determine product yield and quality. This is particularly true for the next-generation of mRNA therapeutics that are substantially larger and more complex than previously studied mRNA products. These products offer potential to improve patient outcomes by delivering enhanced therapeutic efficacies at reduced doses. However, we currently lack the required tools to optimise manufacture of these ‘difficult-to-produce’ molecules.

　　In this collaborative project with AstraZeneca, we will use a synthetic biology approach to design new biological components for production of next-generation mRNA therapeutics. This will include core synthetic biology techniques such as DNA sequence design, directed evolution of proteins, high-throughput screening of biological systems, bioanalytics, and machine learning. Specifically, the project has the following objectives:

　　i) Understand how RNA polymerase and promoter sequence features govern their ability to produce large, complex mRNA molecules.

　　ii) Design and test libraries of novel, synthetic RNA polymerase-promoter pairs.

　　iii) Design and engineer an RNA polymerase-promoter system that is specifically optimised to manufacture next-generation products at high yields, reduced cost and enhanced quality.

　　This is an excellent opportunity for a postgraduate student who is passionate about synthetic biology and keen to make a positive contribution to a project with direct bioindustrial application. The student will join an active research group (20+ members) with extensive industry-links, working at the cutting edge of biopharmaceutical development, design and manufacture. Working in our molecular biology, bioanalytical, microbial and cell culture laboratories, equipped with up-to-date industrially-relevan technologies/equipment, the student will obtain skills and capabilities that are in high-demand in both academia and the biopharmaceutical/biotechnology industry. The student will carry out a research placement at AstraZeneca and will receive an enhanced stipend (￡20,668 PA).

　　The BBSRC WR DTP and the University of Sheffield are committed to recruiting future scientists regardless of age, ethnicity, gender, gender identity, disability, sexual orientation or career pathway to date. We understand that commitment and excellence can be shown in many ways and we have built our recruitment process to reflect this. We welcome applicants from all backgrounds, particularly those underrepresented in science, who have curiosity, creativity and a drive to learn new skills.

　　Entry Requirements

　　The ideal candidate will have (or expect to obtain) a first or upper second class degree (or equivalent) in a relevant discipline such as biology, molecular biology, biochemistry, biotechnology, bioengineering or chemical engineering (with a biology-based specialism).