美国关于新冠肺炎病毒后遗症的一项研究，结论可能你想不到！

　　今天看到位于美国纽约的阿尔伯特·爱因斯坦医学院和蒙蒂菲奥里医学中心（Department of Radiology, Albert Einstein College of Medicine and Montefiore Medical Center）Iosifescu, Andrei L.等5位学者发表在《国际精神病学研究方法杂志》对COVID‐19新冠后遗症的一项研究。

　　英文摘要：

　　Objectives: Neurological and neuropsychiatric manifestations of post‐acute SARS‐CoV‐2 infection (neuro‐PASC) are common among COVID‐19 survivors, but it is unknown how neuro‐PASC differs from influenza‐related neuro‐sequelae. This study investigated the clinical characteristics of COVID‐19 patients with and without new‐onset neuro‐PASC, and of flu patients with similar symptoms. Methods: We retrospectively screened 18,811 COVID‐19 patients and 5772 flu patients between January 2020 and June 2021 for the presence of new‐onset neuro‐sequelae that persisted at least 2 weeks past the date of COVID‐19 or flu diagnosis. Results: We observed 388 COVID‐19 patients with neuro‐PASC versus 149 flu patients with neuro‐sequelae. Common neuro‐PASC symptoms were anxiety (30%), depression (27%), dizziness (22%), altered mental status (17%), chronic headaches (17%), and nausea (11%). The average time to neuro‐PASC onset was 138 days, with hospitalized patients reporting earlier onset than non‐hospitalized patients. Neuro‐PASC was associated with female sex and older age (p < 0.05), but not race, ethnicity, most comorbidities, or COVID‐19 disease severity (p > 0.05). Compared to flu patients, COVID‐19 patients were older, exhibited higher incidence of altered mental status, developed symptoms more quickly, and were prescribed psychiatric drugs more often (p < 0.05). Conclusions: This study provides additional insights into neuro‐PASC risk factors and differentiates between post‐COVID‐19 and post‐flu neuro‐sequelae. [ABSTRACT FROM AUTHOR]

　　中文翻译：

　　急性SARS-CoV-2感染后（神经PASC）的神经和神经精神表现在COVID-19幸存者中很常见，但神经PASC与流感相关神经后遗症的区别尚不清楚。这项研究调查了COVID-19患者的临床特征，包括有和没有新发神经PASC的患者，以及有类似症状的流感患者。方法：我们回顾性筛选了2020年1月至2021 6月期间的18811名冠状病毒19型患者和5772名流感患者，以确定是否存在新发神经后遗症，该后遗症在冠状病毒或流感诊断日期后至少持续2周。结果：我们观察到388名COVID-19患者患有神经PASC，而149名流感患者患有神经后遗症。常见的神经PASC症状包括焦虑（30%）、抑郁（27%）、头晕（22%）、精神状态改变（17%）、慢性头痛（17%）和恶心（11%）。神经PASC的平均发病时间为138天，住院患者报告发病时间早于非住院患者。神经PASC与女性和老年人相关（p<0.05），但与种族、种族、大多数合并症或COVID-19疾病严重程度无关（p>0.05）。与流感患者相比，COVID-19患者年龄更大，精神状态改变的发生率更高，出现症状的速度更快，并且更经常服用精神药物（p<0.05）。结论：本研究为神经PASC风险因素提供了更多的见解，并区分了COVID-19后和流感后神经后遗症。[作者摘要]

　　来源|国际精神病学研究方法杂志。本文仅供学术交流！